
Manchester United captain Rio Ferdinand returns to the team after a four-game absence with a back injury.
Patrice Evra is also back after his four-match ban, so United have only Owen Hargreaves and Wes Brown missing.
Chelsea welcome back captain John Terry for the trip to Old Trafford after he served a three-match suspension.
Michael Ballack is also available after a ban and Jose Bosingwa should play despite picking up a knock, but Florent Malouda (hamstring) misses out.
Man Utd (from): Van der Sar, Kuszczak, Foster, Neville, Rafael, Vidic, Ferdinand, Evans, Evra, O'Shea, Ronaldo, Nani, Fletcher, Carrick, Scholes, Giggs, Park, Berbatov, Rooney, Welbeck, Gibson, Possebon.
Chelsea (from): Cech, Cudicini, Hilario, Bosingwa, Ferreira, Ivanovic, Terry, Alex, Mancienne, A Cole, J Cole, Obi, Lampard, Kalou, Anelka, Drogba, Stoch, Carvalho, Di Santo, Deco, Mineiro, Belletti, Ballack.
Manchester United boss Sir Alex Ferguson:
"Because Chelsea are one of the top teams in the country, there is more spice to it and more anticipation amongst the players.
"I don't think there's been much change in the Chelsea team other than the swing in terms of home and away form.
"They are still consistent, they are still very difficult to play against and they still have very good players."
Chelsea midfielder Frank Lampard:
"The errors have been very frustrating for everyone involved because we do work on them in training anyway.
"Sometimes it has been an individual error or a collective one, but it has been very important because we have dominated the last two games and we lost out on a set-piece in the final minute each time.
"We can't afford to let that happen against a team of Manchester United's calibre."
This eagerly awaited heavyweight clash at Old Trafford could be a defining match in the title race, as both clubs bid to make up ground on leaders Liverpool.
Chelsea go into the weekend three points behind the Merseysiders; Manchester United are seven points off the pace, and four points behind the Blues with two games in hand on both.
The top home club faces the top away club, going into this round of top division fixtures. United are unbeaten at Old Trafford; Chelsea unbeaten on the road so far in this Premier League campaign.
Chelsea are the first of the 'Big Four' clubs to visit Old Trafford this season; United have drawn one (at Chelsea) and lost two (v Arsenal and Liverpool).
The Red Devils are the first of the 'Big Four' Chelsea have faced away from home; Scolari's side have already lost to Liverpool and Arsenal at Stamford Bridge.
The last time Chelsea turned up at Old Trafford for a Premier League match, Jose Mourinho had just left the club, and Avram Grant took charge for the first time. The Blues lost 2-0.
Defeat for the home club will be their 150th league loss under Sir Alex Ferguson, and 300th home defeat in top-flight football; defeat for the Blues will be their 100th Premier League loss away from home.
Chelsea had to rely on a headed goal from Salomon Kalou 10 minutes from time to salvage a point from a pulsating reverse fixture in September. Park Ji-sung had given United the lead in the 1-1 draw.
Manchester United have conceded more goals (43) and dropped more points (58) to Chelsea than to any other club in the Premier League.
The Red Devils were the last club to beat Chelsea in a Premier League game by more than a single goal (23 September 2007); Chelsea were the last club to beat United by more than a single goal (29 April 2006).
Distance between the clubs: 204 miles (328 kilometres)
Key Players:
MANCHESTER UNITED
Cristiano RONALDO is yet to score a Premier League goal against Chelsea.
Edwin VAN DER SAR is leading the race for the Barclays Golden Glove, along with Jose REINA of Liverpool and Chelsea's Petr CECH. All three have kept 11 clean sheets, ahead of this current round of fixtures.
If selected:-
Rio FERDINAND will be making his 200th Premier League appearance for Manchester United.
CHELSEA
Kose BOSINGWA and Frank LAMPARD are the only remaining players to have started all of Chelsea's Premier League matches this season.
Nicolas ANELKA is the top-scoring Premier League player with 16 club goals in all competitions, and is leading the race for the Barclays Golden Boot with 14 Premier League goals.
Petr CECH is level with Liverpool's Jose REINA and Manchester United's Edwin VAN DER SAR, in the race for the Barclays Golden Glove. All three have kept 11 clean sheets (going into this weekend's fixtures).